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Anyway, at higher concentrations, like those deriving from a high-fat diet, primary and secondary BAs can reduce gut barrier integrity with their detergent properties, causing increased intestinal permeability and, thus, oxidative stress, DNA damage, and production of inflammatory cytokines, such as IL-6 and TNF-alpha, which promote inflammation and cause the inactivation of the FXR, thereby powering a pro-inflammatory state in the colon [25]

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All handling should be performed in a controlled laboratory environment by trained personnel using appropriate containment practices

Kang Nien, H., et al

It signals the pituitary gland to release a pulse of growth hormone

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