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Nanoparticles for vaccine and gene therapy: overcoming the barriers to nucleic acid delivery

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Severe and potentially life-threatening reactions like pancreatitis, bowel obstruction or infection of the gallbladder are also possible, although less common

In addition, some sHSPs, such as HSPB1/HSP27 and HSPB5, can be phosphorylated through kinase pathways, including the p38/MK2 pathway, which may regulate their chaperone activity, cytoskeletal interactions, and involvement in autophagy-related clearance of damaged cellular components (Ungelenk et al., 2016