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Unfortunately, one-third of cancer patients succumb to the disease within five years of diagnosis, primarily due to tumor recurrence [1, 6]

Emerging evidence underscores the centrality of FA metabolism perturbations in driving disease progression, from hyperuricemia-triggered crystal deposition to sustained NLRP3 inflammasome activation, ultimately forming a self-perpetuating metabolism-immunity axis

Moreover, the phenotypic penetrance of genetic variants overlaps with other disorders such as attention deficit hyperactivity disorder, which is highly dependent on an individuals genetic background

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The gut-brain connection is real and well-documented