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To address this, researchers have developed stimuli-responsive PEG-shedding systems that react to tumor-specific cues such as acidic pH or elevated reductive potential, facilitating PEG detachment and enhancing cellular internalization [108, 109]
Erratum in: Proc Natl Acad Sci USA 1999;96:10944
adults, according to the VA
Male C57BL/6J mice were anaesthetized with i.p
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Describing herself as largely 'the lab rat' when she joined the diabetes team, Knudsen remembers she spent 'the first year in a cold room with three technicians to screen hundreds of thousands of compounds to see if they could wedge into the GLP-1 receptor and other targets of interest just snugly enough to stimulate insulin secretion.' To help speed up the screening process, Knudsen devised a method to test 96 candidates in one go instead of just one
