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This FDA-approved treatment offers a dual-action approach, using GLP-1 and GIP receptor agonists to effectively reduce appetite, slow down digestion, and improve blood sugar control
It helps skin cells regulate water balance because it functions as an osmolyte
Obesity drugs that demonstrate benefits in cardiovascular disease, chronic kidney disease, sleep apnea, MASH, and metabolic syndrome may command stronger payer support and longer treatment duration
(15(1)):87 doi:10.1186/s13023-020-01371-2
Aside from the advantage of having higher appeal to people who are squeamish with needles, oral formulations remove the need for cold chain storage for injectable forms of GLP1R/GIPR/GR agonists , which otherwise must be stored at cold temperatures if not provided in a dry (Tablet/pill) form
Metformin requires renal function monitoring and is contraindicated when eGFR falls below 30 mL/min/1.73m
