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In line with this, confocal analyses displayed a P4HA1 signal in the area of the pancreatic tumor lesion negative for the epithelial marker E-cadherin (E-Cad) and for the pancreatic epithelial tumor Pan-cytokeratin (PanCK) and a co-localization with the CAF marker alpha-smooth muscle actin (aSMA) (Fig

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Evidence: In major trials, participants achieved substantial weight loss, with higher doses producing the largest average reductions