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As a specialist knee surgeon in Sydney, Dr Jonathan Negus is comfortable having open conversations about emerging treatments and where they currently fit in evidence-based knee care

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Early studies in obese individuals showed some reductions in body fat mass, but findings are not consistent across trials: In one clinical trial, AOD9604 did not demonstrate statistically significant weight loss compared to placebo, suggesting its fat-burning effects may be modest without lifestyle intervention (summary of trials)

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