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GLP-1 RAs should be considered as an add-on to SGLT2i therapy for those with cardiometabolic complications with elevated HbA1c, BMI 35 kg/m 2 , and comorbidities
However, results are not guaranteed, can take several months to become visible, and require consistent treatment to maintain
To further verify the differences, subgroup-based stratified analyses and sensitivity analyses from the FAERS database were conducted using four disproportionality algorithms
A literature review also found that the proportion of lean body mass reductions varied between 20% and 50% of total weight lost, which is in line with diet-induced weight loss and bariatric surgery
With ongoing support and healthy habits, many patients sustain their weight loss over the long term
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