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SURMOUNT-1: Tirzepatide for Obesity The SURMOUNT-1 trial (NEJM, 2022) studied tirzepatide weight loss in 2,539 adults with obesity (without diabetes) over 72 weeks: STEP 1: Semaglutide for Obesity The STEP 1 trial (NEJM, 2021) studied semaglutide 2.4mg in 1,961 adults with obesity (without diabetes) over 68 weeks: Cross-Trial Summary Comparing across trials (with the caveat that indirect comparison has limitations): tirzepatide 15mg produced about 6 percentage points more weight loss than semaglutide 2.4mg over similar timeframes
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35-54 Age Group Emerges as Key Target Demographic The 35-54 age group held a 30.6% share in 2024 and is forecast to reach 33% in 2025
For example, instead of 1.0 mg once weekly, you take approximately 0.43 mg every three days
Tau interactome maps synaptic and mitochondrial processes associated with neurodegeneration
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