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Combining tretinoin with other medications Acne is often treated with a combination of two or more medications at the same time, which is commonly referred to as combination treatment. Combination therapy aims to address multiple factors that contribute to acne development, such as excess oil production, bacterial growth, inflammation, and abnormal skin cell shedding

Its use in humans outside an FDA-authorized clinical trial is illegal

Learn more about each stage by reading our How to Build a Skincare Regimen guide

A 2026 UK evidence review of the estrogen-BDNF-HGF axis, HRT first, and realistic expectations

10.1016/j.celrep.2015.02.012 21 akrT.zkanE.DulunduE.Topalolu.ehirliA.ErcanF.et al (2011)