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Gastrointestinal Side Effects and Dehydration Nausea and vomiting are among the most commonly reported gastrointestinal side effects of GLP-1s

Several medical societies, including the American College of Obstetricians and Gynecologists, note that GLP-1 medications should ideally be discontinued before conception planning begins

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In contrast, the gdh3 / gdh3 mutant showed overall higher concentrations of intracellular metabolites than the wild-type strain when grown in MM medium, except for 2-aminobutyrate and norvaline.When grown in a proline medium, the gdh3 / gdh3 mutant revealed a significantly higher concentration of glutamate family metabolites (e.g., glutamate, glutamine, and proline) than the wild-type, whilst asparagine, histidine, phenylalanine, valine, leucine, tyrosine, and aspartate family metabolites (e.g., aspartate, isoleucine, and threonine), as well as all saturated fatty acids detected, were at lower concentrations in the gdh3 / gdh3 mutant