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What pathological process could be responsible for a very slow, multifocal white matter degeneration that seems to track along connected pathways

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31 This preconditioning effect, often termed ozonated autohemotherapy, can activate the nuclear factor erythroid 2-related factor 2 pathway, leading to enhanced synthesis of antioxidant enzymes, such as heme oxygenase-1 and glutathione reductase