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JAK2 activation in BPC-157-treated tendon fibroblasts occurs in a time-dependent manner following growth hormone stimulation, indicating the peptide primes cells for enhanced growth factor responsiveness rather than directly activating the pathway in the absence of the endogenous ligand
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Furthermore, glucocorticoids enhance myostatin expression, thereby negatively impacting skeletal muscle (69,158)
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Warner MA, Meyerhoff KL, Warner ME, Posner KL, Stephens L, Domino KB
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