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BMJ Journals
Introduction GLP1 medications like semaglutide (Ozempic, Wegovy) and tirzepatide (Mounjaro, Zepbound) work by mimicking a hormone your body already makes called glucagon-like peptide-1
This prolonged half-life is achieved through albumin binding via a C20 fatty diacid moiety attached to the peptide backbone
In the STEP 1 trial, patients on semaglutide 2.4 mg lost an average of 14.9 percent of their body weight over 68 weeks
Regarding blood sugar control , these medications work through multiple complementary pathways
Kamath S, Chan NSL, Joyce P
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