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The single published human case series and unpublished clinical trial data provide preliminary safety reassurance but insufficient evidence for clinical efficacy claims
However, the independent confirmation by Sun et al
Food additives, contaminants and other minor components: Effects on human gut microbiotaA review
Immediate medical attention is necessary if these symptoms occur
81 A study in anxious dogs showed treatment with the probiotic yeast Saccharomyces boulardii, at 1 billion CFUs per kg of dog food daily for 35 days, decreased levels of cortisol, suggesting stress reduction
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