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Succinic acids as potent inhibitors of plasmid-borne IMP-1 metallo--lactamase

For documented deficiency, loading doses of 1000 mcg daily or several times weekly for 1 to 2 weeks rapidly restore tissue levels

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In one study, participants lost about 1.3 kilograms more than placebo in 16 days, and the drug reduced daily caloric intake by roughly 400 calories per day, suggesting appetite suppression via melanocortin-4 receptor (MC4R) activation

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