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found that GLP-1 and exendin-4 could completely protect cultured rat hippocampal neurons against glutamate-induced apoptosis (191)

Unlike exogenous HGH, which floods the body continuously, Ipamorelin promotes rhythmic, biologically aligned growth hormone pulses but it must be timed properly to do so

[100] [101] [102] However, high amphetamine doses that are above the therapeutic range can interfere with working memory and other aspects of cognitive control

GHRP-2, as a full agonist, drives the receptor above this baseline, but the existence of constitutive activity is part of why the ghrelin/GHS-R1a axis behaves as a rheostat on GH output rather than a simple on/off switch

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