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doi: 10.1016/j.clnu.2006.05.002 43

Adenovirus and lentivirus infection To overexpress PCSK5, the recombinant adenoviruses encoding the human PCSK5 gene (Ad-PCSK5) and or the recombinant adenoviruses encoding the PCSK5 variant lacking amino acids 158164 (Ad-PCSK5 158164aa ) or blank control adenoviruses (Ad-Ctrl) (Hanbio, Shanghai, China) and the recombinant lentivirus encoding the human PCSK5 gene (Lenti-PCSK5) and or the recombinant lentivirus encoding the PCSK5 variant which mutated Arg158 and Asn164 of PCSK5 with alanine (Lenti-PCSK5 mut ) or blank control lentivirus (Lenti-Ctrl) (PackGene Biotech, Guangdong, China) were used

Please allow 30 to 45 minutes

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Lyophilized (freeze-dried) peptide remains stable for extended periods at room temperature or longer when refrigerated

Cognitive Functioning/Dementia At least 5 studies (1 case-control, 1 cohort, 3 RCTs) discussed the role of GLP-1 agonists and their action in AD and dementia