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12 prepared a series of novel ebselen derivatives, and also a tellurium analogue 42 , Figure 10
Increase in thiol oxidative stress via glutathione reductase inhibition as a novel approach to enhance cancer sensitivity to X-ray irradiation
Phase-2-Daten zeigten starke Gewichtsreduktion
The precipitate is then suspended in water, wherein the glutathione can be released by reaction with hydrogen sulfide or the salts thereof (CN106220708) or by an electrochemical process (EP2439312, WO2014/133129)
Unlike apoptosis, the orderly form of programmed cell death, ferroptosis is driven by iron-dependent oxidative damage to cell membranes
These proteins play a crucial role in iron metabolism, particularly in the biogenesis of FeS clusters, as well as in the transport of iron [38,39] (Figure 1)
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