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Sun protection prevents ongoing melanin production sabotaging brightening peptide efforts - daily broad-spectrum SPF 30-50 including eye area (or wearing sunglasses with adequate coverage), reapplication every 2 hours during extended outdoor exposure, seeking shade during peak UV hours 10am-4pm, and wearing wide-brimmed hats providing additional eye area protection

This function is mediated by binding of SMN to the Sm proteins through its Tudor domain, with the arginine-, glycine-rich (RG) domains on SmB, SmD and SmD3

10.1016/j.jdiacomp.2016.02.003 213 TbaraL

Simeon A, Wegrowski Y, Bontemps Y, Maquart F

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The RAI therapy, while effective, often causes hypothyroidism, and this requires lifelong replacement with thyroid hormones