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For head and neck squamous cell carcinoma (HNSCC) [183], HYAL1 demonstrates potential as a tissue-specific biomarker, with elevated HYAL1 and PH20 expression observed in laryngeal carcinoma specimens [184]
Inhibitory profile of selected potent compounds is shown in Supplementary Table 7
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The authors hypothesized that an increasing GSH concentration represents an adaptive mechanism to increase antioxidant defenses, which results in fewer symptoms, reduced airway reactivity, and milder disease in patients with asthma
However, because glutathione is so good at neutralizing reactive substances, too much of it can deplete other nutrients that the body needs for proper function
