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7 units = 350mcg/175mcg

Normal distribution was tested visually on a histogram of the residuals and differences between group means or medians were assessed using ANOVA and post-hoc analyses using Tukeys post-hoc test

In the stomach, hydrochloric acid and pepsin release B12 from food proteins, after which intrinsic factora glycoprotein produced by gastric parietal cellsbinds to the vitamin

For those exercising in hot climates or who generally sweat a lot when exercising, fluid loss is a significant health and performance concern

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I start low and increase gradually: Standard Protocol: Week 1: 1.5mg daily (at bedtime) Week 2: Increase to 3mg daily Week 3+: Maintain at 4.5mg daily (the optimal dose for most conditions) Sensitive Patient Protocol: Start at 0.5mg with weekly increases of 0.5mg Stay at each dose level for 2 weeks Stop increasing when you get the best response instead of automatically going to 4.5mg Special Considerations: POTS patients often do best at 2.53mg Long COVID patients usually follow standard escalation to 4.5mg CIRS patients may need even slower increases to avoid detox reactions Always take at least 24 hours after any binding agents or medications Most patients take LDN at bedtime, though those getting vivid dreams can switch to morning without losing effectiveness