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The potential main mechanism responsible for SGLT2-i reno-protective properties probably resides in TGF activation and glomerular hyperfiltration reduction
For the future, scientists are investigating how it could address metabolic disorders other than obesity, including non-alcoholic fatty liver disease and insulin resistance
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In line with these observations, recent findings indicate that the appetite-suppressing actions of GLP-1RAs may also be mediated through receptors located in circumventricular organs outside the BBB
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