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14 Centers for Disease Control and Prevention (CDC)Subcutaneous injection technique: angle, site and no-aspiration guidance
From SURMOUNT-1 reanalysis at week 4: 2.5 mg arm: average weight change -1.2% (about 2.5 lb for a 200 lb starting weight) 5 mg arm: average weight change -2.1% (about 4.2 lb) 10 mg arm: average weight change -2.6% (about 5.2 lb) 15 mg arm: average weight change -2.9% (about 5.8 lb) Placebo arm: average weight change -0.4% The headline 21% weight loss number from SURMOUNT-1 is the 72-week result at 15 mg
Higher doses reached that plateau later in the trial. In a 112-week step-down trial, participants maintained 21.9% loss on the top dose, 16.6% after stepping down to 5 mg, and 9.9% on placebo
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