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Steady-state concentrations are achieved after roughly 4 weeks of consistent weekly dosing, at which point there is about 1.6-fold accumulation compared to a single dose

In these patients, the cause is usually not a blood vessel compressing the trigeminal nerve at the brainstem, but irritation of the nerve somewhere along its course in the face

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This timing allows you to confirm tolerance to the initial dose before diving into deeper genetic insights that may inform future dose optimization or consideration of alternative compounds

These insights support a safe, personalized approach while helping identify any potential risks