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It sensitizes tumors by inhibiting PARP1-mediated autophagy while reducing cisplatin-induced organ damage
FIGURE 2 Gene ontology and Kyoto encyclopedia of genes and genomes pathway enrichment analysis results of differentially expressed genes The results of GO analysis showed that the molecular functions of differential genes mainly included pseudouridine synthase activity, BMP receptor binding, xylosyltransferase activity, proton antiporter activity (sodium, monovalent cation, potassium), calcium-dependent protein kinase activity, low-density lipoprotein particle receptor activity, transferase activity, and transferring glycosyl and pentosyl groups
Peptides can be powerful tools, but dosage and monitoring are key to avoiding side effects and maximizing benefits
Clinical trials show patients on metformin who added tirzepatide achieved 9-11 kg weight loss over 40 weeks, substantially more than metformin's typical 1-3 kg reduction alone
[Accessed 26/01/2026]
Weight loss should never come at the expense of feeling unwell or depleted
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