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Compared with acute pain, chronic pain is known to be much more harmful to the human body (93)

This susceptibility is further supported by significantly lower GPX4 expression in primary AML samples compared with normal bone marrow (P=1.3106), along with reduced GSH levels and increased mitochondrial lipid peroxidation (162)

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doi: 10.1038/35025220 86 LorussoGRueggC

& Milne, R

However, the medication's gastrointestinal side effects like constipation and diarrhea may indirectly increase hemorrhoid risk in susceptible individuals