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Therapeutics based on mitochondrial dysfunction and oxidative stress, such as mitochondria-targeted antioxidant [10-(4,5-dimethoxy-2-methyl-3,6-dioxo-1,4-cyclohexadien-1-yl)decyl]triphenylphosphonium methanesulfonate (MitoQ), modify disease progression by slowing the decline of mitochondrial function and disease progression in the SOD1 G93A mouse model of ALS (Miquel et al., 2014)

PubMed / Current Pharmaceutical Design

Total RNA isolation, cDNA synthesis, and qRT-PCR TransZol RNA kit (ET101-01, TransGen Biotech) was used to extract total RNA from Arabidopsis plants according to manufacturers instructions

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