The relationship between diabetes and cognitive impairment involves many aspects, including central insulin signal transduction, nerve fiber damage caused by hyperglycemia, neuritis, oxidative stress, bloodbrain barrier damage, vascular neuropathy, changes in the dopaminergic system, and the effects of advanced glycation end products on metabolism and energy (Figure 1)
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Biologics modulation of lipid metabolism primarily operates through two fundamental mechanisms: (1) enhancing hepatic clearance of lipoproteins via upregulation of low-density lipoprotein receptor (LDLR) activity and (2) directly altering the composition, modification, and metabolism of atherogenic lipoproteins
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