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Plant J 9(4):513523

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335 Additionally, lactateHCAR1 signaling in tumor cells activates the 14-3-3STAT3 axis, promoting CCL2/CCL7 production and recruitment of CCR2 PMN-MDSCs, which suppress T cells via ARG1 and ROS, thereby limiting PD-1 blockade efficacy

The potential effects on fetal development and the unknown presence in breast milk make these peptides inappropriate for use during pregnancy or breastfeeding