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One posited mechanism is the activation of phospholipase C (PLC), which, according to some researchers, might subsequently facilitate the release of inositol triphosphate (IP3) and diacylglycerol (DAG)
Although Th2-associated cytokines, such as IL-4 and IL-13, may promote fibrogenic responses, the overall contribution of Th2 cells to MASH is still inconclusive (127, 128) ( Figure 6A )
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