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Benvenga S, Bartolone L, Squadrito S, Lo Giudice F, Trimarchi F
Additionally, DZN has been reported to induce mitochondrial permeability transition through a mechanism sensitive to cyclosporin A, EGTA, ruthenium red, and N-ethylmaleimide, potentially leading to mitochondrial Ca 2+ efflux and cytochrome c release triggered by ROS [10]
It is plausible, though untested, that targeted modulation of GLP-1R activity could maximize the beneficial effects of GLP-1 while minimizing potential adverse effects, particularly in conditions involving metabolic dysfunction, cardiovascular health, or other age-associated pathologies
In addition, circadian meal timing and intermittent fasting can align hormonal rhythms and enhance GLP-1 signaling (Sutton et al., 2018)
M., Davlieva, M., Strych, U., Hill, R
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