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(2006) 141b:94756
N Engl J Med (2015) 373:211728
Endpoints frequently measured include the activity of alkaline phosphatase (ALP), an early marker of osteoblast differentiation, the expression of the master osteogenic transcription factor Runx2, and the deposition of a mineralized matrix, which can be visualized with Alizarin Red staining
However, this trial was limited by small sample size and potential flaws in the selection of endpoints (NCT04916470 and NCT05371496) [52]
GLP-1RA (such as exendin-4) treatment can reduce the size of MI impacted cardiac volume in rats, inhibit ventricular dilation, myocardial fibrosis and hypertrophy in vivo [72]
Results vary by individual.
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