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Consequently, a significant proportion of administered nanocarriers is prematurely sequestered and cleared by the reticuloendothelial system (RES)particularly the liver and spleensubstantially limiting the effective dose that reaches the osteosarcoma TME (69, 70)
PMID 14648529
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This makes delivery immediate, but immediate delivery is not the same as proven superiority
10.4103/2278-0513.142618 51 PatilS.SahuR.SghaireenM.KunsiS.MaheshwariS
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