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If susceptible mouse strains are used in research, the more severe diffuse lesions may occur
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Animal studies have demonstrated that the administration of pyruvate, the end metabolite of glycolysis, can achieve neuroprotection by normalizing metabolic disturbances and antagonizing zinc neurotoxicity following global ischemia (16)
If the same vial were diluted with 4mL instead, the concentration would be halved to 5,000mcg/mL, and the same 4,000mcg dose would require 0.8mL, or 80 units
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Clinical trials are ongoing, and Novo Nordisk has indicated plans to file for approval
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