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Researchers are studying additional indications for GLP-1s that would extend focus beyond diabetes and obesity

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The tertiary structure of the enzyme is stabilized by an extensive network of salt bridges, hydrogen bonds and van der Waals interactions (Thoma et al., 2003)

Exclusion criteria included: type 1 diabetes, either acute or chronic pancreatitis, proliferative diabetic retinopathy or macular diabetes, non-proliferative diabetic retinopathy requiring urgent treatment, either acute or chronic hepatopathy with clinic or laboratory evidence of liver injury (e.g., 3-fold elevation in plasmatic transaminases), severe hypoglycemia or unawareness hypoglycemia, gastroparesis, previous bariatric surgery, concomitant use of certain medications delaying gastric emptying, established coronary disease or severe chronic heart failure (NYHA class III or IV), glomerular filtration rate 50%

Following a virtual screening of the SPECS database, along with enzymatic activity experiments, 17 novel compounds were created

Strategies to minimize symptoms include slower titration schedules, maintaining adequate hydration, and consuming smaller, more frequent meals