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Where semaglutide and tirzepatide work through incretin pathways, cagrilintide targets amylin receptors in the brain to reduce appetite and slow gastric emptying through an entirely separate signaling cascade
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In our review, we summarize evidence from randomized clinical trials and meta-analyses showing that ten approved and emerging obesity medications can improve a remarkably broad range of obesity-related conditions, including: Liver disease (MASLD and MASH) Chronic kidney disease PCOS (now increasingly referred to as PMOS, polyendocrine metabolic-ovarian syndrome) Obstructive sleep apnoea Osteoarthritis and physical functioning Cardiovascular disease Prediabetes and type 2 diabetes Importantly, many of these benefits are related to weight loss itself
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Zhang et al., 2019b)
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