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GLP-1 receptor agonists like semaglutide are peptides that influence appetite, blood sugar, and metabolism
2011, Jan, 22;45(1):10109 Alderson NL, Wang Y, Blatnik M, Frizzell N, Walla MD, Lyons TJ, et al
However, in a more recent randomized, placebo-controlled study in 102 subjects, daily supplementation with 600 mg of lipoic acid (+/- 800 mg of vitamin E [-tocopherol]) for 16 weeks had no effect on fasting blood glucose, fasting blood insulin, or a measure of insulin resistance called the homeostatic model assessment of insulin resistance (HOMA-IR) index (59)
First, there's the liver