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Because GLP-1RA use can cause both anti-inflammatory healing benefits and adverse nutritional depletion, the association of GLP-1RA usage with surgical complications remains under investigation

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Upon stimulation by agents such as VEGF, the binding of eNOS and Cav-1 is released, eNOS associates with calmodulin, and then subsequently phosphorylated by heat shock protein 90 and AKT 23

However, elderly patients may have decreased kidney function and may be more sensitive to side effects like nausea, vomiting, and dehydration, which could impact kidney health