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In the context of acquired resistance, PDX models can be subjected to repeated drug exposure to mimic disease progression observed in patients transitioning from initial sensitivity to resistance
Your liver makes most of it, and your supply drops as you get older
Modification of histones can affect the exposure of the DNA nucleotide sequence and thus affect the transcription level of the gene
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Its not a trendits a transformation
Science Transl Med
[1] These effects are typically mild to moderate, most pronounced during dose escalation, and tend to diminish over time
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