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[19] [21] Typical adult doses for the treatment of vitamin C deficiency range from 200 mg to 1 g daily, administered intravenously, with higher doses (up to 100 grams per day) reserved for specific clinical protocols under close supervision

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Some studies suggest the quinolinium structure is sufficiently NNMT-selective that it should not broadly deplete SAM, but the wider metabolic picture remains an active research consideration

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