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RNA modifications in mitochondria-related cuproptosis Cuproptosis, a novel form of regulated cell death that is dependent on copper metabolism, has been implicated in various diseases [254,255,256]

In future designs of nanozyme-based delivery systems, more consideration should be given to modifying the enzyme conformation so that it can still respond to the substrate through allosteric effects after carrier loading

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Treatment efficacy can also be monitored by evaluating markers of cuproptosis, which are upregulated before treatment and downregulated following successful therapy [137] , including FDX1, DLAT, lipoic acid synthetase (LIAS), aconitase 2 (ACO-2), succinate dehydrogenase complex iron-sulfur subunit B (SDHB), procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 (PLOD1), and dihydropyrimidine dehydrogenase (DPYD)

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