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A further possibility is that the positive chronotropic effect could be, at least partially, mediated by sympathetic nervous system enhancement, related to the inhibition of the autonomic nervous system [18, 36, 37]

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The SURMOUNT-1 trial (Jastreboff et al., 2022, New England Journal of Medicine) found that gastrointestinal side effects were among the most commonly reported adverse events with tirzepatide