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Hamilton A, Zhang Q, Salehi A et al (2018) Adrenaline stimulates glucagon secretion by Tpc2-dependent Ca(2+) mobilization from acidic stores in pancreatic alpha-cells

When activated, glucagon receptors increase energy expenditure through thermogenesis, promote lipolysis, which is the breakdown of stored fat, and enhance fatty acid oxidation in the liver

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Shen et al., 2007

These definitely have a genetic component and tend to run in families