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When pups were tested for reproductive performance at maturation, gestational weight gain, number of implantations, and number of delivered pups were decreased in the group whose mothers had been given 10 mg/kg

Nature 454, 10591062 (2008)

Here is what happens when NNMT is overactive: Your cells store more fat and burn less energy NAD+ levels drop (a critical molecule for energy production and cellular health) Insulin sensitivity decreases (making it harder to control blood sugar) Inflammation increases in fat tissue Metabolism slows down According to research in PMC, NNMT expression is upregulated in the white adipose tissue of obese and diabetic mice

As an essential vitamin, it contributes to the bodys ability to convert food into glucose, providing energy

Lancet Reg Health Eur