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Certain GLP-1 receptor agonists appear capable of crossing into the brain, which raises the possibility of direct neurological effects
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Improved insulin sensitivity becomes measurable on labs
doi: 10.1080/21505594.2021.1878688 23 ChoD
Following this, there have been two clinical phase 2 trials (SAR425899 and MEDI0382 also known as cotadutide) published evaluating GLP-1/glucagon receptor co-agonists
It acknowledges that some people still report muscle tightness or cramping in real-world use
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