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Intraperitoneal injection of PMX500FI not only significantly reduced cell apoptosis in the photoreceptor layer of a mouse retinal detachment model and alleviated the inflammatory response accompanied by retinal detachment but also broadly protected the thickness of the outer nuclear layer, thereby maintaining the structural integrity and functional efficacy of the retina [322]

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The dose is raised slowly by 2.5 mg at a time, no sooner than every four weeks in a process called titration that keeps side effects manageable

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For example, the acetylation-deficient TP53 variant, TP53[3KR], lacks the ability to induce apoptosis and cell cycle arrest but retains its tumor suppression function akin to wild-type TP53

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