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On the other hand, elevated cAMP levels by forskolin, an activator of adenylyl cyclase, can render a blocking action on Kv channels and subsequent prolongation of action potential duration, generating a resultant increase of insulin secretion ( As an important controller in the repolarizing process of the -cell action potential, the large-conductance calcium-activated K + (BK Ca ) channels also participate in modulating the depolarization-induced insulin release, evidenced by BK Ca blockade enhancing human -cell AP amplitude and insulin secretion ( Ca ( + channels that contributes to insulin release ( + channels influencing the insulin secretion could be more complicate due to the inconsistency of experimental observations

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