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However, it may not be enough, especially if oxidative stress is severe or has been prolonged
Samnegrd A, Hulthe J, Silveira A, et al
INH is a prodrug that enters the Mtb cytoplasm via passive diffusion, where it inhibits mycolic acid synthesis by targeting the InhA enzyme, an essential catalyst in an early step of the mycolic acid biosynthetic pathway (Mitchison, 1956)
Cell Biosci 15 , 57 (2025)
That conversion depends on liver enzymes and methyl donors such as folate
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