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S-adenysyl methyltransferase (SAM) is a strong inhibitor of MTHFR , which also makes it the major regulator of folate-dependent homocysteine remethylation

In this regard, the translational relevance of this preclinical study was demonstrated in patients with obesity by correlation of: (1) circulating FGF21 levels 4 weeks after mRYGB with the initial fat mass and one-year body weight reduction, (2) circulating FFAs with 4 week-body weight loss in mRYGB patients and (3) circulating adiponectin and OXM with weight loss